Synthetic route design and execution
Hit selection, Hit to Lead, Lead optimization
Route scouting, selection and development
Process research and optimization
Heterocyclic, sugar and nucleoside chemistries
Specialized in addressing challenging chemistries
Short and long synthesis routes
Non-GMP kilo-labs with separate hoods for each set of reactor / rotary evaporator
Up to 10Mpa (Max. 10L reactor)
Up to 50 psi (50L SS reactor)
Temperature: -100℃ to 250℃
Pressure reactions
Open-access analytical lab (HPLC, GC, LC-MS)
On-site QC and QA for supporting production
Dynamic Axial Compression Chromatography System (DAC-150)
Both reverse and normal phase separation
Max. loading 20-100 grams for each injection
Provide up to a few 100 grams of product purification
Service Scope: Drug Substance Production for IND, API preparation for Phase I to II (1-10kg per batch)
Dedicated production team working in shifts to ensure continuous production
Compliance with GMP's requirements (China/US)
Production Area
4 production lines with 50-100L reactors
1 separated prep-HPLC room
DAC150 and DAC100
50L rotary evaporator
Both reverse and normal phase separation
Max. loading 10-50 grams for each injection
Provide up to a few 100 grams of product purification
Clean Area
Separated Clean Room (100K Asepsis)
Crystallization/isolation/drying/packaging
50L and 200L reactors for crystallization
Jet milling for Micronization (D90=10µm)
Lyophilization capability (2kg/day)
Dedicated warehouses with controlled humidity and temperature, solid raw materials, liquid raw materials, intermediates, products
Well maintained purified water system compliant with Pharmacopoeia requirement
Audit trail analytical equipment
Dedicated GMP compliant QC team
On-site QA team
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