About us
Services & Solutions
Chemistry Drug Metabolism and Pharmacokinetics (DMPK) Discovery Biology Oncology Pharmacology Biologics
Medicinal Chemistry Parallel Synthesis Peptide Chemistry Computational Chemistry Synthetic Chemistry Analytical Chemistry Scale Up Chemistry
In Vivo PK and TK In Vitro ADME Bioanalytical Service Toxicity In Rodents, Dogs and Monkeys Large Molecule Development and Bioanalysis
Fragment Based Drug Discovery (FBDD) Biochemical Assays Cellular Assays Protein Science Assay Technologies Biophysics SPR Safety Pharmacology Screening Services Key Instruments
PDX CDX Orthotopic Models Syngeneic Models Humanized Mouse Models CAR-T and CAR-NK Mouse Models In Vitro Assays
Immunology Inflammation Metabolic MASH Mouse Models Respiratory Neuroscience
Systematic Antibody Discovery Service
Process R&D Scale Up Synthesis DS Manufacturing
Flow Chemistry Sugar Chemistry Peptide Chemistry Preparative Purification Capacity Process Safety Assessment
Synthetic and Scale Up Chemistry
Kilo and Pilot Scale Production RSM and Intermediates Manufacturing QA EHS
Preformulation Formulation, Analytical, and Process Development Drug Product Manufacturing
Hot Melt Extrusion (HME) Spray Dried Dispersion (SDD) Amorphous Solid Dispersions (ASD) Bioavailability Enhancement Modified Release
Clinical Manufacturing Commercial Manufacturing
Platforms
News & Resources
Careers
Contact us
×

Integrated Drug Discovery

Home Platforms Integrated Drug Discovery
Overview: BioDuro-Sundia IDD Platform
BioDuro-Sundia offers fast, flexible contract services to advance novel drug discovery efforts in the areas of chemistry, biology, DMPK, and others. Our full-circle Integrated Drug Discovery (IDD) Platform encompasses PK, ADME, Biology, Pharmacology, Medicinal Chemistry, and Synthetic Chemistry together to accelerate solutions across hit identification, hit-to-lead, as well as lead optimization. Our IDD Platform accelerates drug discovery programs all the way to preclinical candidate (PCC) selection.
We are flexible to operate along the spectrum from a supportive role where our clients drive the design, or a collaborative model where we design together, to a fully integrated mode where we primarily drive the MedChem/CADD design.
IDD Project Management Ensures Short Cycle Times
Each IDD project retains a dedicated project manager with a deep understanding of the drug discovery process (PM) as the central point of contact (POC) between clients and BioDuro-Sundia technical staff to coordinate resources, align stakeholders, and track progress cross-functionally.
By setting clear governance and effective communication structures, our dedicated PM helps to ensure all key stakeholders stay aligned and can make the appropriate data-based decisions in real-time.
Our dedicated PM customizes, optimizes, and monitors workflows to drive seamless ‘Full-Circle’ integration between early-to-late discovery stage service lines to ensure smooth and fast handoffs and thus shorter cycle times.
IDD Solutions for Early- and Late-Stage Discovery Programs
We employ distinct and customized ‘Fit-for-Purpose’ drug discovery strategies to increase success rates. Smarter design focused on fewer compounds reduces time and cost when compared to the common approach of broad synthesis of many compounds “because they can be made”.
Our ‘Fit-for-Purpose’ IDD Platform informs timely and frequent ‘Go / No-Go’ decisions based on a defined screening cascade towards a clear target product profile (TPP).
We can engage clients at any stage, starting with early hit identification and hit services, or starting with late lead de-risking and forward-thinking backup strategies.
Typical Timeline of BioDuro-Sundia IDD Program:

Hit ID - Quality and diversity of initial hits determines chance of success; careful triage is essential.

LO - Ideally progress multiple, structurally distinct and patentable lead series and progress into late LO as early as possible – don’t wait for the “perfect” molecule, but move several differentiated compounds forward if possible.

H2L - Focus on creating novelty and FTO through scaffold-hopping, nitrogen-walk, unique building blocks, while monitoring drug-likeness parameters and ADME early; taking advantage of handles for quick parallel SAR exploration.

Late LO/PCC - Narrow down to 2-3 compounds to select for PCC candidate and backup compound(s); connect with PRD and FormDev (“Solution Engine”) scientists early.

Integrated Discovery Biology: The Foundations of Outstanding IDD
BioDuro-Sundia’s broad biology experience in key therapeutic areas and across all major target classes are the foundation enabling integration of the entire drug discovery cycle.
Our strong expertise providing custom assay development and validation services as well as in vivo pharmacology models in key therapeutic focus areas help generate crucial data for quick and frequent no/no-go decisions.
Therapeutic focus areas:

Oncology

Immunology & Inflammation

Metabolic disorders

Target classes:

Enzymes

G-protein coupled receptors (GPCRs)

Nuclear hormone receptors

Ion channels

Epigenetics-related targets

Modality focused platforms:

TPD platform

Oligonucleotide drug platform

Peptides

Antibodies and ADCs

Enabling platforms:

Gene editing

Stable cell line generation

Protein science

Biophysics and fragment-based drug discovery (FBDD)

In-vitro safety assays

Download the PDF
Visit bioduro-sundia.com/downloads.html to learn our detailed IDD capabilities and download the latest IDD flyer in PDF format.
Contact Us
We can engage clients at any stage, starting with early hit identification and hit services, or starting with late lead de-risking and forward-thinking backup strategies. Access a full range of discovery services under one roof from Hit ID to PCC.
Send us questions and inquiries - hello@bioduro-sundia.com
Peptide Drug Discovery
Compound Management
PROTAC Drug Discovery
Bioavailability Enhancement
Integrated Drug Discovery
IND Enabling
DNA-Encoded Library
Preclinical MASH Models
Subscribe to BioDuro-Sundia
Receive our newsletter and information on upcoming events
Your trusted partner from drug discovery and
development to commercialization

Home

About us

Services & Solutions

Platforms

News & Resources

Careers

Contact us

Explore

Discovery

Drug Substance

Drug Product

© 2023 BioDuro-Sundia. All rights reserved
Terms of Use Privacy Policy
We use necessary cookies to ensure our website functions properly and to keep it secure. These necessary cookies must be enabled. By clicking “Accept All Cookies”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. You can personalize or withdraw your consent at any moment by clicking on the link "Cookies Settings". For more information on how we use cookies, including the total lifespan of cookies and the identity of third parties intervening on our website, please consult the Privacy Notice available in the site footer.
Accept all