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Chemistry Drug Metabolism and Pharmacokinetics (DMPK) Discovery Biology Oncology Pharmacology Biologics
Medicinal Chemistry Parallel Synthesis Peptide Chemistry Computational Chemistry Synthetic Chemistry Analytical Chemistry Scale Up Chemistry
In Vivo PK and TK In Vitro ADME Bioanalytical Service Toxicity In Rodents, Dogs and Monkeys Large Molecule Development and Bioanalysis
Fragment Based Drug Discovery (FBDD) Biochemical Assays Cellular Assays Protein Science Assay Technologies Biophysics SPR Safety Pharmacology Screening Services Key Instruments
PDX CDX Orthotopic Models Syngeneic Models Humanized Mouse Models CAR-T and CAR-NK Mouse Models In Vitro Assays
Immunology Inflammation Metabolic MASH Mouse Models Respiratory Neuroscience
Systematic Antibody Discovery Service
Process R&D Scale Up Synthesis DS Manufacturing
Flow Chemistry Sugar Chemistry Peptide Chemistry Preparative Purification Capacity Process Safety Assessment
Synthetic and Scale Up Chemistry
Kilo and Pilot Scale Production RSM and Intermediates Manufacturing QA EHS
Preformulation Formulation, Analytical, and Process Development Drug Product Manufacturing
Hot Melt Extrusion (HME) Spray Dried Dispersion (SDD) Amorphous Solid Dispersions (ASD) Bioavailability Enhancement Modified Release
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Chemistry

Drug discovery through advanced chemistry. Enhancing projects with cutting-edge expertise in medicinal, synthetic, and computational chemistry.

Home Services & Solutions Discovery Chemistry Scale Up Chemistry

Scale Up Chemistry

Overview
We deliver non-GMP intermediates and final compounds from grams to multi-kilograms
Highlights

Address challenging chemistries with expert teams

Perform complex heterocyclic, sugar & nucleoside chemistries with long synthesis routes

Flexible to meet project needs

Fast turnaround time

Reproducible high-quality data

Services

Multi non-GMP Kilo Labs

FTE & FFS

Process scale-up

Gram to Kg scale of non-GMP RSM, intermediate, API (for non-clinical use)

Synthesis of intermediates, building blocks, references, metabolites, impurities

Synthesis of non-GMP tox & clinical materials

Capabilities

2L - 20L Reactors; 50L Separatory flasks

Centrifuge

20L Evaporators

DSC (TA, Q20)

Drying oven

HPLC, UV, IR, NMR

Chemistry
Medicinal Chemistry Parallel Synthesis Peptide Chemistry Computational Chemistry Synthetic Chemistry Analytical Chemistry Scale Up Chemistry
Drug Metabolism and Pharmacokinetics (DMPK)
In Vivo PK and TK In Vitro ADME Bioanalytical Service Toxicity In Rodents, Dogs and Monkeys Large Molecule Development and Bioanalysis
Discovery Biology
Fragment Based Drug Discovery (FBDD) Biochemical Assays Cellular Assays Protein Science Assay Technologies Biophysics SPR Safety Pharmacology Screening Services Key Instruments
Oncology
PDX CDX Orthotopic Models Syngeneic Models Humanized Mouse Models CAR-T and CAR-NK Mouse Models In Vitro Assays
Pharmacology
Immunology Inflammation Metabolic MASH Mouse Models Respiratory Neuroscience
Biologics
Systematic Antibody Discovery Service
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