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Discovery Biology

Cutting edge technologies supporting a broad array of services including discovery, preclinical and translational assays.

Home Services & Solutions Discovery Discovery Biology Biophysics SPR

Biophysics SPR

Overview
Surface Plasmon Resonance (SPR) is a core Biophysical technique used at BioDuro-Sundia. We have a state-of-the-art SPR system and Biacore 8K (GE) at our Shanghai site.
SPR for Biologics

Affinity Maturation

Hot Spot Analysis/Stress Test

Fc Engineering

Anti-drug Antibodies (ADA)

Epitope Binning/Mapping

BsAb Construction

CAR-T scFv Screening and Selection

Antibody-Drug Conjugate (ADC)

Epitope Mapping

IND Package

Specificity Study

Cross-Reactivity

FcRn

FcγRs

C1Q

SPR for NCE

Compound binding affinity

Full binding kinetics and binding stoichiometry

Residence time

Fragment library screening

Chemistry
Medicinal Chemistry Parallel Synthesis Peptide Chemistry Computational Chemistry Synthetic Chemistry Analytical Chemistry Scale Up Chemistry
Drug Metabolism and Pharmacokinetics (DMPK)
In Vivo PK and TK In Vitro ADME Bioanalytical Service Toxicity In Rodents, Dogs and Monkeys Large Molecule Development and Bioanalysis
Discovery Biology
Fragment Based Drug Discovery (FBDD) Biochemical Assays Cellular Assays Protein Science Assay Technologies Biophysics SPR Safety Pharmacology Screening Services Key Instruments
Oncology
PDX CDX Orthotopic Models Syngeneic Models Humanized Mouse Models CAR-T and CAR-NK Mouse Models In Vitro Assays
Pharmacology
Immunology Inflammation Metabolic MASH Mouse Models Respiratory Neuroscience
Biologics
Systematic Antibody Discovery Service
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