Overview
BioDuro-Sundia supports the success of simple and complex
peptide drug discovery programs. Our team specializes in process development support for various peptide forms and offers expertise in multiple purification techniques. These peptides include linear, cyclic, branched, and peptide drug conjugates (PDCs).
We utilize state-of-the-art peptide synthesizers, including the Tetra Volo Peptide Synthesizer, CEM MultiPep2 parallel synthesizer and the DL-PSI-286 Peptide Synthesizer, which enable us to synthesize up to 158 peptides simultaneously. These advanced synthesizers allow for approximately eight amino acid coupling reactions per day, providing us with a competitive edge in the global market.
Our peptide synthesis team is supported by an experienced analytical team capable of developing and validating the necessary analytical methods for purification. We employ advanced instruments such as the Waters Prep-HPLC Auto-purification System, Agilent LCMS System, and Shimadzu LC-2050 C Analysis HPLC Systems to ensure the successful completion of this phase.
BioDuro-Sundia Highlights
Over 17 years of extensive experience in peptide chemistry, including both solution and solid-phase synthesis
In-house synthesis of unnatural amino acids, ranging from gram to kilogram scale, using robust methods
Expertise in backbone and side chain modification of peptides
Synthesis of macro cyclopeptides with diverse structures, including lactam, RCM, disulfide bonds, thioether, and click chemistry
Synthesis of metallo-peptide-chelate and PDC compounds
Comprehensive assays for potency (biochemical and cell-based) and DMPK evaluation
Routine ePSA tests (SFC) for permeability prediction and evaluation
Key instruments
PTI Symphony X
・0.1-0.2 mmol
・N2 protection
・24 channels
CEM MultiPep2
・0.1-0.2 mmol
・Heating model
・48 channels
Tetras Volo
・0.1-0.5 mmol
・108 channels
DL-PSI-286
・0.2-3 mmol
・N2 protection
・Heating model
・3 channels
Related Resources
Peptide Drug Discovery and Development
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