Shanghai, November 15, 2023 – Radioisotope assay is a microanalytical method that uses radionuclides as tracers to label research objects. Compared with conventional biological sample detection techniques, Radioisotope assay has distinct advantages such as high specificity, high sensitivity at the nanomolar level, short detection time, accurate positioning, and quantification, etc. Especially, it has unsurpassed specificity and sensitivity in the detection of membrane receptors such as GPCR receptor-ligand binding affinity test and extracellular substance uptake assays. However, due to strict management requirements and high maintenance costs, only a few CRO companies can provide such services.

BioDuro-Sundia’s radioisotope laboratory in Jiangsu, China is part of the in vitro biology department of our drug discovery business unit, which mainly provides in vitro pharmacological assays and metabolic assays based on cellular or biochemical reactions. In July 2023, the BioDuro-Sundia Jiangsu R&D center was formally granted the Radiation Safety Permit by Jiangsu Province, which allows for BioDuro-Sundia to purchase and use unsealed radioactive materials for radiometric experiments and to conduct R&D services for in vitro pharmacological efficacy testing based on isotope methods, which greatly enhances our technical service strength in the development and analysis of innovative drugs.

Since obtaining the Radiation Safety Permit, BioDuro-Sundia is able to undertake preclinical studies related to radionuclide markers including ³⁵S, ³²P, ³³P, ¹²⁵I, ¹⁴C, ³H, providing an integrated platform for compound screening and MOA verification:

  ● Integrated compound screening and MOA study services for epigenetic targets including METTL3/14, P300&CBP, G9a&GLP and PRMT5.

  ● Radioligand-binding assay, including GPCR receptor-ligand binding affinity test.

  ● Radioactive kinase assay for kinase inhibitor screen.

  ● Uptake assays by using radio isotope method, such as glucose uptake.

  ● GTPγS binding assays for GPCR agonists screen.

  ● Radioimmunoassay experiment, metabolite identification experiment and other customized detection requirements.

Our radioisotope laboratory in Jiangsu, China is BioDuro-Sundia’s third isotope laboratory with this qualification, building on the extensive experience of the two established isotope laboratories. The laboratory is equipped with a MicroBeta2 TriLux scintillation counter with 12 detectors, high sensitivity, and high accuracy, and a Sorval LYNX 4000 high-speed centrifuge with 4L capacity and 68,905 x g acceleration performance, which can easily achieve high-speed separation. To date, we have completed radioligand receptor binding assays and MOA assays for a number of domestic and international clients and received consistent praise from our clients for delivering data with high accuracy.

GPCR agonist competitive binding assay

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Methyltransferase Inhibitor Assay

Enzymatic Method Development Process

MOA Assays

BioDuro-Sundia will continue to improve our radiometric assay platform to provide high-quality technical services for new drug innovation and accelerate the development of biopharmaceuticals. Our discovery biology team in Jiangsu R&D center has accumulated extensive experience in method development and compound screening using biochemical and cell-based phenotypic-functional assays to conduct research services for targets of different classes. We are equipped with state-of-the-art laboratories and sophisticated instruments, providing a wide range of technical support for projects including in vitro discovery of small molecule drugs, cell line establishment, recombinant protein production and customized biology services. For each project, we deliver project-relevant, high-quality data with fast project turnaround time. Our chemists, drug discovery biologists, and drug metabolism and pharmacokinetic (DMPK) experts collaborate closely to provide clients with the flexibility to customize their services in a variety of modalities.

About BioDuro-Sundia

BioDuro-Sundia, an Advent International portfolio company, is a trusted, leading contract research development, and manufacturing organization (CRDMO) for over 27 years. We provide our biotech and pharmaceutical partners with fully integrated services to support their efforts from target identification through to commercial drug product manufacturing. The company is based in the US and China with more than 3,000 employees and 9 global sites across 6 cities.

Core expertise includes small and large molecule discovery, development and scale up, support for IND submission, and unique technology platforms such as bioavailability enhancement of insoluble compounds. The one-stop-shop operation helps biotech and pharma partners across the globe to significantly accelerate discovery and de-risk development to create higher value outcomes. We adhere to one global highest standard of compliance and business operation code. Our science-driven, customer-oriented, people-focused culture enables us to provide top-tier integrated, fast, and flexible tailored services to our customers, to meet their unique needs and accelerate development timelines. For more information, please visit www.bioduro-sundia.com.