PROTAC Drug Discovery Services: Fully Comprehensive Assay Platform
BioDuro-Sundia’s PROTAC assay services provide the most comprehensive biology evaluation platform for PROTAC drug discovery.
Evaluate Target Protein Degration by HiBit Lytic/Kinetic assays
Monitor cell permeability, target engagement using NanoBRET TR-FRET assays
Determine Ternary Complex formation with NanoBRET assays
Observe Degradation Phenotype using assays relevant to your target
Connect with our PROTAC Experts today!
Wide Range of Protein Degradation Assays
- Evaluate endogenous protein degradation using CRISPR-engineered HiBiT cell lines, Western Blot or ELISA
- Minimize evlauation time with sensitive, high-throughput, Live Cell detection assays
- Measure target degradation in real time using HiBiT Live Cell detection assays
- Rank-order compounds by potency with kinetic HiBiT measurements
Advanced Target Engagement and Ternary Complex Formation Determiniation Strategies
- Confirm target engagement with in-cell (NanoBRET) and cell-free (TR-FRET, SPR, TSA) assays
- Rank-order compounds by binding affinity using high-throughput NanoBRET assays
- Save time by testing multiple parameters (occupancy, selectivity, affinity) in one assay
- Verify Ternary Complex formation with reproducible and ratiometric NanoBRET assays
Degradation Phenotype Assays Suited To Your Target
- Downstream signaling assays; e.g. phosphorylation for kinase target, target gene expression for epigenetic targets
- Target-dependent functional assays; e.g. cell viability for cancer therapy targets, T cell function for T cell regulatory targets
Collaborative & Communicative
- PhD-level scientists guide study design and data interpretation
- Study directors located in USA and China
- Dedicated project managers are extensions of your team, focused on timely deliverables