OVERVIEW
SYNTHETIC CHEMISTRY
MEDICINAL CHEMISTRY
COMPUTATIONAL CHEMISTRY
ANALYTICAL CHEMISTRY
SCALE UP CHEMISTRY
In Vitro Adme
High quality in vitro and in vivo studies to help prediction of therapeutic outcomes. Integration with early formulation development studies that enable more accurate scaling of results to humans.
In Vitro ADME
Physicochemical Properties
Metabolic Stability
- Hepatocyte stability
- Liver microsomal stability
- recombinant CYP450 stability
- Liver S9 fraction stability
- Intestine microsomal stability
- Plasma stability
- Blood stability
Permeability Measurement
Distribution
- Plasma protein binding
- Microsomal protein binding
- Tissue protein binding
- Blood to plasma ratio (Cb/Cp)
- Red blood cell to plasma partition (CRBC/Cp)
Transporters
Drug-drug interactions
- CYP450 inhibition (inhibition% or IC50)
- CYP450 time dependent inhibition (inhibition% or IC50 shift)
- CYP450 induction using cryo-preserved hepatocytes (human, rat, mouse)
Metabolite identification and profiling
- Metabolite identification in liver microsomes and other in vitro metabolic reaction systems
- Metabolite identification in plasma and other fluids or tissues from PK or TK studies
- Reactive metabolite GSH trapping
- Metabolite production, isolation, purification and structure determination via in vitro or in vivo metabolic reaction systems