Kinase Assay Panels
Cutting edge technologies supporting a broad array of services including cell line & antibody reagent generation and target validation.
Kinase Assay Panels
- For any kinases that are commercially available or can be produced recombinantly in-house, we can set up the enzymatic assay within a short time frame in either HTRF format (ready for > 160 kinases), ADP-Glo format, or Caliper MSA format
- Measurement of Kinact/Ki for covalent inhibitors
- One-stop service with comprehensive assays to support kinase programs, with examples as below:
JAK family
- Biochemical kinase activity assays for all JAK family members (JAK1-3, Tyk2)
- Pseudo-kinase (JH2) binding assays for Tyk2 and JAK1
- Cellular functional assays for all JAK family members (JAK1-3, Tyk2)
FGFR family
- Biochemical assays for wild-type FGFR1, FGFR2, FGFR3, FGFR4, and FGFR2 (V564I), FGFR3 (V555M), FGFR4 (V550L), FGFR4 (V550M) mutants
- Cellular functional assays for FGFR family members