Biologics
Technologies optimized for best support of discovery & development of biologics products.
Overview
BioDuro-Sundia has built up comprehensive antibody discovery capabilities with differentiation from current market offerings. Multiple technologies are established to discover antibodies from all kind of antibody gene sources, including immunized animals, human patients, and synthetic DNA. Creative strategies will be used to overcome the pain points of therapeutic antibody discovery field with a goal to eventually develop the capability of generating antibodies for not only the typical drug targets but also the more challenging ones, such as GPCRs, ion channels and perhaps even intracellular targets. We are establishing a cutting-edge antibody discovery platform with unique strength and capabilities that will meet the needs of current and future therapeutic antibody discovery and optimization for clients around the world.
BioDuro-Sundia Advantage
- Advanced immunization technologies to generate antibodies for difficult to purify & challenging antigens.
- Efficient clone retrieval, resulting Higher Quality antibody ‘hits’ in less time.
- Biomarker discovery assays performed in non-human primates providing real-life results.
- Cutting-edge AI powered synthetic Ab technology with higher efficiency, developability.
- Advanced therapeutic protein characterization techniques including Intact Mass Analysis, Peptide mapping, Glyco-protein Profiling, Charge of variants & Bind affinity.
- Exhaustive PK/PD service: wide range of animal species, tailored sampling, diverse analytical platforms, specialized Biologics product.
- Flexible business models for the services or collaborations.
- A Biologics team of over 40 scientists with expertise covering antibody discovery, cancer immunotherapy, biophysics, pharmacology, and protein science.
Core Competencies
- Antibody discovery based on synthetic antibody, hybridoma, single B cell technology
- AI powered antibody engineering
- Antibody production
- Antibody binding characterization (Biacore 8K)
- In vitro/in vivo functional assays
Specialized Equipment
- Gyrolab xPLore TM/ Automated Immunoassays
- Triple Quad 6500+ System
- Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer
- Biacore 8K surface plasmon resonance (SPR) system
- ECM 2001+ electrofusion and electroporation system